Heroes of CRISPR Through Twitter’s Eyes: A Sequence


Who knows? Perhaps the story behind the story began here, last October, with a tweet about an article in Wired on “The Heroes of CRISPR.”

Zhang, Sarah. The Battle Over Genome Editing Gets Science All Wrong. WIRED Magazine 10.04.15. http://www.wired.com/2015/10/battle-genome-editing-gets-science-wrong/

Maybe that made someone else think that there really ought to be an article with that title. Although, hints of this arose earlier, with articles like “Who Owns CRISPR?” from last April and “Law, history and lessons in the CRISPR patent conflict” from March, or even the 2014 article “First CRISPR-Cas patent opens race to stake out intellectual property“. In any case, the “Heroes of CRISPR” debate which erupted on Twitter (reaching trending status yesterday) has roots far deeper than the article of the same name, which triggered the flood, or even the US Patent Office’s recent insertion into the CRISPR patent battle.

Zhang, Sarah. An Arcane Patent Law May Decide Crispr’s Big Legal Fight. WIRED Science 01.05.16. http://www.wired.com/2016/01/crispr-patent-dispute-gets-really-arcane/

The early tweets were mostly supportive, creating awareness of what is genuinely an eloquent and educational article, especially for those outside the field. There were, however, hints of the later discord even among the earliest tweets. Later concerns arose more from informed readers on the inside of the professions working with CRISPR and aware of the personalities and politics behind the piece, and then snowballed.

* Early Tweets about ‘Heroes of CRISPR’
* The Heat rises
* The Response(s)
* Ongoing debate
* More information

EARLY TWEETS ABOUT ‘HEROES OF CRISPR’

12:48 PM – 14 Jan 2016

1:17 PM – 14 Jan 2016

1:33 PM – 14 Jan 2016

1:47 PM – 14 Jan 2016

2:09 PM – 14 Jan 2016

3:52 PM – 14 Jan 2016

4:01 PM – 14 Jan 2016

4:50 PM – 14 Jan 2016

5:52 PM – 14 Jan 2016

6:22 PM – 14 Jan 2016

6:38 PM – 14 Jan 2016

6:44 PM – 14 Jan 2016

7:26 PM – 14 Jan 2016

8:22 PM – 14 Jan 2016

1:35 AM – 15 Jan 2016

3:17 AM – 15 Jan 2016

7:02 AM – 15 Jan 2016

7:35 AM – 15 Jan 2016

8:11 AM – 15 Jan 2016

9:04 AM – 15 Jan 2016

9:10 AM – 15 Jan 2016

12:26 PM – 15 Jan 2016

THE HEAT RISES

10:31 AM – 15 Jan 2016

10:36 AM – 15 Jan 2016

10:49 AM – 15 Jan 2016

11:18 AM – 15 Jan 2016

12:41 PM – 15 Jan 2016


We Can Now Edit Our DNA. But Let’s Do it Wisely | Jennifer Doudna | TED Talks https://www.youtube.com/watch?v=TdBAHexVYzc

6:55 PM – 15 Jan 2016

THE RESPONSE(S)

4:01 PM – 16 Jan 2016

4:03 PM – 16 Jan 2016

4:11 PM – 16 Jan 2016

4:14 PM – 16 Jan 2016

4:21 PM – 16 Jan 2016

4:24 PM – 16 Jan 2016

5:44 PM – 16 Jan 2016

4:12 PM – 17 Jan 2016

5:51 AM – 17 Jan 2016

PubPeer on Heroes of CRISPR

11:43 AM – 19 Jan 2016

11:57 AM – 19 Jan 2016

1:19 PM – 19 Jan 2016

ONGOING DEBATE

3:19 PM – 18 Jan 2016

7:04 PM – 18 Jan 2016

3:33 PM – 19 Jan 2016

3:48 PM – 19 Jan 2016

3:54 PM – 19 Jan 2016

4:11 PM – 19 Jan 2016

5:06 PM – 19 Jan 2016

5:24 PM – 19 Jan 2016

5:30 PM – 19 Jan 2016

6:56 PM – 19 Jan 2016

6:58 PM – 19 Jan 2016

7:08 PM – 19 Jan 2016

7:45 PM – 19 Jan 2016

7:46 PM – 19 Jan 2016

7:52 PM – 19 Jan 2016

"Heroes of CRISPR" commentary

9:56 AM – 20 Jan 2016

MORE INFORMATION

USPTO: CRISPR Patents: http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=0&f=S&l=50&TERM1=crispr&FIELD1=&co1=AND&TERM2=&FIELD2=&d=PTXT

March 6, 2014. Doudna Patent, Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription (US 20140068797 A1). http://www.google.com/patents/US20140068797

Apr 15, 2014: Zhang Patent, CRISPR-Cas systems and methods for altering expression of gene products (US 8697359 B1) http://www.google.com/patents/US8697359 | http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,697,359.PN.&OS=PN/8,697,359&RS=PN/8,697,359

July 11, 2015: CRISPR – Will This Be the Last Great US Patent Interference? http://blog.patentology.com.au/2015/07/crispr-will-this-be-last-great-us.html

November 9, 2015: The Crispr Quandary:  A new gene-editing tool might create an ethical morass — or it might make revising nature seem natural. http://www.nytimes.com/2015/11/15/magazine/the-crispr-quandary.html?_r=0

December 29, 2015: The CRISPR Patent Interference Showdown Is On: How Did We Get Here and What Comes Next? https://law.stanford.edu/2015/12/29/the-crispr-patent-interference-showdown-is-on-how-did-we-get-here-and-what-comes-next/

January 8, 2016: DuPont in CRISPR-Cas patent land grab http://www.nature.com/nbt/journal/v34/n1/full/nbt0116-13.html

January 12, 2016: For journalists: Statement and background on the CRISPR patent interference process https://www.broadinstitute.org/what-broad/areas-focus/project-spotlight/journalists-background-patent-process

January 12, 2016: USPTO Declares Interference Proceeding to Adjudicate CRISPR Patent Spat https://www.genomeweb.com/business-news/uspto-declares-interference-proceeding-adjudicate-crispr-patent-spat

January 12, 2016: Bitter fight over CRISPR patent heats up http://www.nature.com/news/bitter-fight-over-crispr-patent-heats-up-1.17961

January 13, 2016: USPTO ignites CRISPR/Cas9 patent battle http://www.lifesciencesipreview.com/news/uspto-ignites-crispr-cas9-patent-battle-1280

January 13, 2016: Control of CRISPR, biotech’s most promising breakthrough, is in dispute https://www.washingtonpost.com/news/wonk/wp/2016/01/13/control-of-crispr-biotechs-most-promising-breakthrough-is-up-for-grabs/

January 15, 2016: CRISPR Patent War: Billions at Stake for UC Berkeley http://ww2.kqed.org/futureofyou/2016/01/15/crispr-patent-war-billions-at-stake-for-uc-berkeley/

January 16, 2016: A Brief History Of The Gene-Editing Tool That Is Changing Science, Scientists have now actually watched the DNA-editing tool in action http://www.vocativ.com/news/263157/crispr-cas9/

January 19, 2016: Controversial CRISPR history sets off an online firestorm http://www.statnews.com/2016/01/19/crispr-history-firestorm/

January 20, 2016: A social media war just erupted over the biotech innovation of the century https://www.washingtonpost.com/news/wonk/wp/2016/01/20/is-a-history-of-biotechs-hottest-breakthrough-propaganda/

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