Infographic of the Week: 8 Early Warning Signs of Domestic Violence

Beauty Cares: #1 of 8 warning signs in nine languages
Beauty Cares: 8 Warning Signs of Domestic Violence: http://beautycares.org/signsofdomesticviolence/

I was extremely impressed when I discovered the Beauty Cares: Education = Prevention Tour on the topic of domestic violence. They have a wonderful infographic that spells out eight of the most common indicators forewarning of a relationship that is more likely to become a battering relationship in the future.

There are so many things I like about this it is hard to choose where to start. I like the information, and the design. I like that they say, “DOWNLOAD AND SHARE!” at the bottom of all the graphics. I like that they translated it into so many languages (some of which you see in the picture at the top of this post).

But what I like most is how they are using this in schools. When I first saw this my first thought was, “I wish they had a full course curriculum in every high school where this image was the syllabus!” Well, they aren’t taking this that far, but they are taking it into the schools as part of a formal outreach program. I found blogposts on recent visits to four schools (with many more in the blog archive): Mary Louis Academy; Cathedral High; St. Joseph’s; & Long Island University.

Just imagine a room where a teen girl tells a story about a recent date, and other teens erupt at one point in the story, “Unhunh, girl, that’s CONTROL. He’s trying to make all your decisions. What do YOU want?” Where all the teens know these and recognize them when they see them, and get conversations going around them. It could be so powerful.

I’ve showed this to a few married couples, too. Happily married couples. It seems (in my experience) as if it is pretty normal to have a couple of these show up in a healthy relationship, every now and then, and not at extreme levels. Still, they are there. So don’t go feel like you must leave a relationship immediately if you see one of these. But if you see several of them, or any one of them is WAY over the top and out-of-control, or it doesn’t come and go but is there ALL the time … well, you might have a problem. Also, think about what are YOU doing in your relationships? How many of these do your partner have to put up with? Feeling sheepish? Well, we’re only human. But do try to be aware, and try to get it under control. If you can’t do it yourself, get help. And if your partner can’t get it under control, get help, and get out. Even if getting out is just until they do learn how to control themselves better.

But there are folk who can say it better than I can, and who know a lot more about it than I do. Here is a video from the Beauty Cares channel, followed by the complete infographic. (You were wondering what the other seven signs are, weren’t you?)


Aryn Quinn: Preventing Domestic Abuse & Teen Dating Violence https://www.youtube.com/watch?v=VZLBj2opJP8

PDF: http://beautycares.org/wp-content/uploads/2012/12/SHARE-THE-8_-21-years-and-up.pdf

Beauty Cares: 8 warning signs of domestic violence

Beauty Cares: 8 Early Warning Signs of Domestic Violence:
1. Intensity
2. Jealousy
3. Control
4. Isolation
5. Criticism
6. Sabotage
7. Blame
8. Anger

Learn about Making, 1: Going on NOW! [#makehealth]

First posted at @HealthByUs https://medium.com/@HealthByUs/learn-about-making-1-ae9cc7ff1e70


Maker learning events NOW

Maybe you’re not in Washington, New York City, or San Francisco. Maybe you’re not in Chattanooga, Pittsburgh, or Boston. Maybe you’re not even in Ann Arbor! But you want to know more, you want to do more, and you want find other people to do things with you, to share learning and making and troubleshooting. We’re going to do a series of blogposts on exactly that, on topics like videos, online classes, maker communities, online spaces, books and blogs. To get you started we’re highlighting three special events going on right now, just as examples: MakerCamp & Tinkering Course & the Google Science Fair.


MakerCamp ScreenshotsMakerCamp Screenshots
MakerCamp ScreenshotsMakerCamp Screenshots

MAKERCAMP

The annual Maker Camp is a several week even each summer, while kids are out of school. Officially, it is designed to engage kids and have activities at an appropriate level, but, I can tell you, a lot of what they do is just as challenging and fun for adults as for kids. Each week has a different theme, and here’s the line up for this year, followed by links to more information and an example video of them showing folk how to DIY safety features for your bicycles.

Week 1: Makers in Motion
Week 2: Art & Design
Week 3: Fun & Games
Week 4: Science & Technology
Week 5: DIY Music
Week 6: Make: Believe

Maker Camp: http://makercamp.com
MakerFaire: Maker Camp 2014: http://makerfaire.com/makers/maker-camp-2014/
G+: Make Media: MakerCamp: https://plus.google.com/+MAKE/posts
G+: Communities: Maker Camp: https://plus.google.com/communities/107377046073638428310


MakerCamp: Beautiful 3D Printing: https://plus.google.com/events/c1137mvrqi1o3i4o8t5s891egbk


Tinkering Studio & FundamentalsTinkering Studio & FundamentalsTinkering Studio & Fundamentals
Tinkering Studio & FundamentalsTinkering Studio & FundamentalsTinkering Studio & Fundamentals
Tinkering Studio & FundamentalsTinkering Studio & FundamentalsTinkering Studio & Fundamentals

TINKERING FUNDAMENTALS

I cannot tell you how excited I was when I saw this MOOC (an online class) was coming from Coursera and the Tinkering Studio folk! Unfortunately for me, the class is going on at exactly the same time that we are swamped with planning our own MakeHealth event. I hope that they offer it again!

A MOOC is a Massively Open Online Course, usually from teachers famous for the topic. In this case, the Tinkering Studio is part of the famous Exploratorium, one of the most recognized museums based on the hands-on science learning approach. Even though I can’t do what’s needed for the assignments in the class, I am lurking in the hangouts and watching as many videos as I can fit in. They’ve done a phenomenal job of integrating social media, which you will notice from the links below. They are also asking the students to use social media to turn in their homework, posting videos of the robots of light shows and photos of objects. Here is the very high level overview of their course content, followed by links and an example video from one of the hangouts.

Week One: Introduction to Tinkering
Week Two: Initial Explorations
Week Three: Learning Dimensions
Week Four: Tinkering Tenets and Personal Expression
Week Five: Coding, Computation and Facilitation Strategies
Week Six: Putting It All Together

Tinkering Fundamentals: A Constructionist Approach to STEM Learning https://www.coursera.org/course/tinkering
Exploratorium: Tinkering Studio: http://tinkering.exploratorium.edu
Art of Tinkering (book): http://www.artoftinkering.com
G+: The Tinkering Studio: https://plus.google.com/116350164652876977257/posts
Facebook: Tinkering Studio: https://www.facebook.com/thetinkeringstudio
Twitter: Tinkering Studio: https://twitter.com/tinkeringstudio
Instagram: Tinkering Studio: http://instagram.com/TinkeringStudio/
Youtube: Tinkering Studio: https://www.youtube.com/channel/UCtx1xfSh01cJ8WYsFeKt7RQ/feed


Week Four Hangout On Air: Tinkering Fundamentals: https://www.youtube.com/watch?v=OeV-h6LGoAM


Google Science FairGoogle Science FairGoogle Science Fair
Google Science FairGoogle Science FairGoogle Science Fair
Google Science FairGoogle Science FairGoogle Science Fair

GOOGLE SCIENCE FAIR

We’ve had a camp, a course, and now a science fair! Google Science Fair (GSF or #GSF2014) is actually something kids work on all year. The main event is coming up early in August, and is usually live-streamed. This is less about learning how to make things, and more of an inspiration to see what kids are doing with science and technology. For us, of course, part of the real excitement is seeing how kids are doing research to support health and learning about health. Here are some of the topics being highlighted at this year’s GSF.

* Acidic pH determines if Cryptococcus neoformans can survive in the environment and within the host
* Haptic feedback e-reader for the visually impaired
* The Synthesis of oleic acid core silica nano particles for the safe delivery of enzymes
* Improving Raloxifene’s affinity with er-Beta through synergy with S-Equol as a novel chemopreventive treatment

… and SO MANY MORE! Several on assistive technology, technology risk, ecology, sustainability, bullying, solar power, bacteriology, stroke management, stem cells, etcetera. In this case, you really have to question what “etcetera” might mean! Again, they are doing an exceptional job of integrating social media, taking things to the next level with an active hashtag, and including a rather sleepy looking blog. Here are some links, and an example video.

Google Science Fair: https://www.googlesciencefair.com/en/
Youtube: Google Science Fair: https://www.youtube.com/user/GoogleScienceFair
Facebook: Google Science Fair: https://www.facebook.com/GoogleScienceFair
Twitter: Google Science Fair: https://twitter.com/googlescifair/
Twitter: #GSF2014: https://twitter.com/hashtag/GSF2014?src=hash
Google Science Fair Blog: http://googlesciencefair.blogspot.com
G+: Google Science Fair: https://plus.google.com/+GoogleScienceFair/posts

Isn’t this just too cool?

Google Science Fair Example Project (Detroit): Caloric Content of Zoo Animal Food: https://www.googlesciencefair.com/projects/en/2014/73efc33fdab7743339937a5a967859c87e4e780ecdfbe31c806553a011c78489


Google Science Fair Project (Detroit): Caloric Intake of Zoo Animal Food: https://www.youtube.com/watch?v=y67sM5ZgkWA


BONUS FEATURE!

Just because it was too cool not to share. Storytelling has become absolutely integral in healthcare because of its power for health literacy and inspiring both community and individual behavior change. In this video, the Maker Camp leaders take a tour of Cartoon Network and the folks behind the very bizarre and popular show Adventure Time, showing the steps behind the process of telling the stories. This goes from concept, to storyboarding, to backgrounds, character design, voicing, and more.


Maker Camp: Cartoon Network Field Trip!: https://www.youtube.com/watch?v=gwfh7ueFy1E

Pubmed is LIVE on Social Media – Hashtags of the Week (HOTW): (Week of July 21, 2014)

Pubmed Social Media Icons
PubMed Update: Social Media Icons Added. NLM Tech Bull. 2014 Jul-Aug;(399):b2. http://www.nlm.nih.gov/pubs/techbull/ja14/brief/ja14_pm_social_media_icons.html

Have you been straddling the fence deciding whether or not social media is “a thing” in healthcare? Well, maybe this will tip the balance. Pubmed now includes social media sharing icons at the article level, as shown in the image above. This is in addition to NIH’s own active life on social media. Unfortunately, when I was testing it out, every now and then what it shared was not the link to the article, but a link to the search strategy from which I found the articles. Hopefully, they’ll get that fixed, but usually it was good. Here’s what it looks like when sharing something to Twitter.

Pubmed Social Media Sharing Example: Twitter

In honor of this noteworthy change, I thought I’d divert from actual hashtags to seeing what people are sharing from Pubmed this week. If you really want hashtags, take a look at what hashtags they are ADDING to the posts, since Pubmed doesn’t automatically add any.


First posted at THL Blog: http://thlibrary.wordpress.com/2014/07/21/pubmed-is-live-on-social-media-hashtags-of-the-week-hotw-week-of-july-21-2014/

[#makehealth] Where the Makers Are

Reposted from:
Health Design By Us: Where The Makers Are (Ann Arbor, MI, a hotbed for #makehealth activities) https://medium.com/@HealthByUs/where-the-makers-are-69288a0a6af3


White House Tweet on Maker Faire

Remember how I was completely blown away by the White House Maker Faire? I just couldn’t stop talking about it.

Afterwards. I was curious about their map, and where the makers seem to be. For the record, since this is all self-report for a single day, and it is measuring tweets, it’s not remotely scientific, and can not give an accurate estimate of maker communities or activity across the US. Really, what it is showing is who on Twitter was aware of the White House maker event in DC. Obviously, DC itself should be big. Since people also self-report their location, there are also strange results like people who just live in the “United States” or “California” but don’t have any other location. I’m not including them in this exercise. That all said, I don’t know of anything that does this better, so for now, it is a start.

#NationOfMakers – USA view
#NationOfMakers Redux

The top three were:
#1: Washington (257)
#2: New York (212)
#3: San Francisco (151)

Just for comparison, the top three cities in the United States by population are New York, Los Angeles, and Chicago. What this hints at is that makers are apparently a separate sub-culture and not evenly distributed thoughout the US. And what it REALLY tells us is where to find a passion for making and the maker movement.

To get all of the top three cities by population included in the list of top cities for makers, but have to go a lot deeper.

1. Washington 257
2. New York 212
3. San Francisco 151
4. San Jose 95
5. Pittsburgh 72
6. Boston 70
7-8. Portland 62
7-8. Chicago 62
9. Chattanooga 51
10. Los Angeles 44

I was also interested in zooming in a little closer to home and seeing how we in Ann Arbor fit in.

East Coast view
Nation of Makers: East Coast

Michigan view
Nation of Makers: Michigan

Now, for comparison, Los Angeles has a population of 3,884,307 with 44 #NationOfMaker tweets. Ann Arbor has 117,025 with 22 #NationOfMaker Tweets (that is adding together those for A2 and those for UMich).

For every 10,000 people in the population, that gives these many tweeting makers who liked the White House Maker Faire:
Los Angeles: 0.11
Ann Arbor: 1.88

I know it doesn’t mean much, but what I’m seeing is a lot more passion for making in Ann Arbor, even though Los Angeles is in the top ten cities in the country for sheer numbers of makers, and top three in the country for population. So I’m calling this a Making Passion Score [(M/P)10,000] where M = makers and P = population of the city, adjusted by 10,000 and limited to 2 decimals. (Note 1: this does give a bias to smaller populations with a lot of excitement. Note 2: Just a hint – that tie between Portland and Chicago is going to look a bit different.) Let’s look at these again, but sorted by Maker Passion Score.

1. Washington 257 / pop. 646,449 = 3.98
2. Chattanooga 51 / pop. 173,366 = 2.94
3. Pittsburgh 72 / pop. 305,841 = 2.35
4. San Francisco 151 / pop. 837,442 = 1.80
5. Boston 70 / pop. 645,966 = 1.08
6. Portland 62 / pop. 609,456 = 1.02
7. San Jose 95 / pop. 998,537 = 0.95
8. New York 212 / pop. 8,405,837 = 0.25
9. Chicago 62 / pop. 2,718,782 = 0.23
10. Los Angeles 44 / pop. 3,884,307 = 0.11

That’s the top ten cities by number of #NationOfMaker tweets sorted by passion. If we look at it that way, Ann Arbor fits in right between Pittsburgh and San Francisco, in 4th place. Wow.

And if that isn’t persuasive evidence for the sheer passion in Ann Arbor for making, then look at this incredible list of community groups around the topic — 67 groups in categories like Coder Groups; Maker Groups; Technology Groups; Talks, Speaker Series, Un/conferences; Hackathons; Office Space, Infrastructure, Resources; Kids Hack Ann Arbor.

Josh Walker: Hack Ann Arbor: http://jshwlkr.github.io/hacka2/

What’s even MORE exciting is that Ann Arbor is just the tip of iceberg for Michigan Makers! There are active communities in Detroit, Jackson, Grand Rapids, the Upper Penisula, and much much more. For Make Health, we are reaching out to as many of these communities as we can in the time allotted. If you belong to one of these, or know someone who does, please share our contact information and help bring making for health together, so we can all help each other.

Here’s more info:

Make Health Fest
Saturday, Aug 16th, 2014
University of Michigan
Palmer Commons, Great Lakes Rooms

The Make Health Fest is a collaborative event for a local and virtual community interested in health, technology, and participatory design. Think of it as a mash-up of science fair PLUS Hands On Museum or Exploratorium PLUS do it yourself!

We are looking for both speakers and exhibitors for the event.

* If you’re gung ho and interested, please complete the official Exhibitor/Speaker sign-up form (http://bit.ly/MakeHealthExhibitorForm) to be a featured exhibitor and/or speaker at the event. Exhibitor and Speaker applications are due by Monday, July 28.

* If you’re interested, but on the fence about exhibiting or speaking just yet, complete the short interest form (http://bit.ly/MakeHealthSignUpForm).

With your help, we hope to promote learning, creating, and problem-solving through a combination of Show+Tell+Do! We’ll be featuring speakers, hands-on learning opportunities, and health innovators from across the community.

Learn More!

Make Health: http://makehealth.us/
Twitter: @MakeHealthUM
Google Plus: Make Health UM

A project of HealthDesignBy.Us
Twitter: @HealthByUs
Blog: https://medium.com/@HealthByUs/we-makehealth-fest-28ea6b472616

Trust & Health Information in Social Media – Hashtags of the Week (HOTW): (Week of July 14, 2014)

BBC Radio4: Reith Lectures 2002: Onora O'Neill, Trust

The question of trust is not a new one — who we trust, how we trust, why we trust. All of these are known to be critical in healthcare, even more so now that we have the Internet and social media. In last’s evening’s #HCSM Twitter chat, a group of patients and doctors debated portions of this question. No new answers or solutions appeared, but there were some provocative statements and perspectives.


First posted at THL Blog: http://thlibrary.wordpress.com/2014/07/14/trust-health-information-in-social-media-hashtags-of-the-week-hotw-week-of-july-14-2014/

Fatigue in Healthcare – Hashtags of the Week (HOTW): (Week of July 7, 2014)

Asleep in the Library

Each week the Healthcare Leaders chat (#HCLDR) is fabulous, covering relevant fascinating topics of great interest to me. I can’t highlight them every week, but I am often tempted to do so. This one was huge — how do we manage fatigue when it impacts on doctors, nurses, residents, students?


First posted at THL Blog: http://thlibrary.wordpress.com/2014/07/07/fatigue-in-healthcare-hashtags-of-the-week-hotw-week-of-july-7-2014/

Good Lord, People, 23andMe is NOT Dead!

Reposting from my personal genomics blog because I think it is important also for the audience of this blog.


23andMe

Good Lord, people, 23andMe is NOT dead! Or closed, or no longer taking orders, or anything like that. I hear this a lot.

“You know, I always wanted to get my genome tested. I was going to try 23andMe, but then the FDA shut them down. Oh, well, missed my chance. [sigh]“

NO! You did NOT miss your chance. Firstly, 23andMe is not closed for business. They still will take your money and your sample. They still will analyze the sample and give you results. From what I’ve been seeing in the results from folk I’ve been helping to look at their data, 23andMe seems to be running the test exactly the same way they always did, for the same SNPs.

They simply are, at this time, not offering their health reports to new customers. It isn’t the data that has changed – it iw what analysis is shared with the customer. Old fogies like me who got their tests done before the FDA folderol” still have access to our old 23andMe health reports, and they continue to improve them.

I have heard nothing to indicate that 23andMe are not working with the FDA to try to make it possible to release health reports again in the future. Issues around that get complicated and I’m going to save them for a later post. Right now, what if you wanted a test for some genetic health information? Can you do it? How long will you have to wait to find out the answers to your health questions?

You can still do it. It isn’t as easy as it was before, but it can be done. I’ve been spending a lot of time talking people through how to do this, and it is time to write it down. If nothing else, it will save me time. This will be the short short version, and I can answer more detailed questions and describe specifics, maybe give an example or two or three.

FIRST, THE DISCLAIMER

Risk is Not Just Genes

Making sense of genetic information is complicated even for experts, which most of us are not. Of course, part of the irony of looking at genetics for health conditions is that most of the time what causes the condition is not just the genetics, but genes PLUS something else. If you don’t find the genes for something, that doesn’t mean you can’t get it; if you do find the genes for something, it doesn’t mean you will get it. It is hardly ever a case of this=that.

What Does Risk Mean, Anyway?

There is also the challenge of figuring out how important the risk is, and whether or not to do something about it. So, my personal risk of celiac disease is over 4 times normal. Wow! That sounds like a lot, doesn’t it? But 4 times normal for celiac risk is still only 1 in 20 people, because normal is about 1 in a hundred. I know someone with celiac risk 17 times normal, which is 1 in 4 people. That’s getting to be pretty serious! But, while celiac is dangerous, it isn’t one of those conditions that is immediately deadly or painful. And my friend still has a 3 in 4 chance of NOT getting celiac, and that is a lifetime risk.

On the other hand, my risk of venous thromboembolism (VTE) is 1.5 times normal. That doesn’t sound like much does it? It’s higher, but only a little bit. So we don’t really need to worry about it, do we? Well, yes. VTE can kill you on the spot, and it is incredibly painful. And normal is 1 in 10 people for lifetime risk. For me, the risk is closer to 1 in 7.

Given that, according to 23andMe, my genetic risk of celiac is roughly 1/20 and my risk of VTE is 1/7, and adding in the comparative dangers of the two diseases, my docs got all excited about the VTE, and not terribly about the celiac. I hope you understand why now, and also a bit more about why genetic risk is complicated.

On Asking for Help

Last part of the disclaimer.

For both of these, celiac and VTE, 23andMe looks at SOME of the genes and SNPs known to be associated with the condition, but not ALL of them. So whatever 23andMe tells me about risk is only part of the picture. It looks at the most important genes, but is still only part of the picture. That’s why you need experts to put all the pieces together, and get more information to fill in the gaps from the 23andMe test.

Everyone always says, “Ask your doctor,” when it comes to finding something puzzling, confusing, contradictory, or worrisome in your genetic tests. I did, and found that most of my doctors didn’t have the expertise to make more out of it than I did. Some poohpoohed the 23andMe results, others made clinical decisions based on them without verifying with other tests, some asked for more medical tests to expand upon what 23andMe had, and one said, “You know more about this than I do, but I’m going to learn.” Here is a quote from an NEJM article a few months ago about the risks and benefits of trusting direct-to-consumer personal genomic services such as 23andMe.

“Clinicians will be central to helping consumer–patients use genomic information to make health decisions. Any regulatory regime must recognize this reality by doing more than simply adding the tagline on most consumer ads for prescription drugs: “Ask your physician.” That is insufficient guidance unless your physician has ready access to a clinical geneticist or genetic counselor.” Annas GJ, Elias S. 23andMe and the FDA. N Engl J Med 2014; 370:985-988. http://www.nejm.org/doi/full/10.1056/NEJMp1316367

Some of the personal genomics service offer phone-in access to genetic counselors. I tried that, and didn’t get helpful answers there, either. Even worse, one of the answers I got was blatantly wrong. It may have been just the genetic counselor who I happened to be talking with, so don’t judge the whole profession by that one person, but do be prepared to keep looking for info if needed. Where I found the most helpful information was in the 23andMe forums, BUT a lot of the info there was unreliable, and I had to sort out what was helpful and what wasn’t.

So, my recommendation is, absolutely DO ask your doctor, ask a genetic counselor if you can, but that might not be enough. You might need to do more research on your own, or find someone you trust to help you with this.

What Good Is It?

So, what good is it then? It gives you clues. Like a detective, you take the clues and look for more information, or ask for more thorough testing, or raise questions that weren’t being asked or addressed before. Some of the clues will be red herrings. Some of them may lead you to a prized solution. For me, these clues ended up dramatically improving my quality of life, and may have even saved my life.


So, now, the short short version. And PLEASE, if someone more expert than me with genomic data reads this and spots any errors, please say so!

PART ONE

1. Get your 23andMe test done.

Pic of the Day - PGenPGEN, Take 2

2. Log in at the 23andMe web site when you are notified that your results are ready.

23andMe

3. Click: Browse raw data.
23andMe: Getting to your raw data

It should look like this:

23andMe: Browse Raw Data

4. Click: Download raw data.
23andMe: Download Raw Data

5. Complete security procedure (log in again, answer security questions, etc.). It should look like this.

23andMe: Downloading Raw Data

6. Answer the question about what type of data and format you want. NOTE: I always choose ALL DNA, unless you have something else specifically in mind.

23andMe: Downloading ALL Your Raw Data Or ...

7. Find the file (which will be named something like genome_Firstname_Lastname_Full_12345678901234.txt)

PART TWO (A): Easier Way

Genetic Genie

Now you have choices. You can dig into the information the easier way, or the less easy way. Let’s start with the easier way.

1. Select a tool to do what you want with your data. There are LOTS of tools people have built to do useful things with 23andMe data files. One of my favorites is Genetic Genie, because it tells you about the MTHFR gene which has become so important in my life. I also am spending a lot of time with Promethease because it is so complete compared to most other 23andMe analysis tools. Lets start with these.

2. Go to the tool of your choice, such as:

Genetic Genie: http://geneticgenie.org/

Promethease: http://www.snpedia.com/index.php/Promethease

3. Follow the directions at the tool, but this almost always requires you to upload your 23andMe data file. Here are more details about doing this with Genetic Genie.

4. Last come what is always the tricky part — making sense of the information you get. That’s worth several posts, but for starters the main point to remember is that the 23andMe test is a place to start, not a final answer. In Genetic Genie, the code, analysis, and text are written by engaged amateurs, not by doctors or genetic counselors. They worked hard, collaborated with a lot of other people, and did a lot of research, but it isn’t going to say the same things your doctor might.

More Tools

23andMe: Tools for Everyone http://www.23andyou.com/3rdparty
NOTE: When 23andMe took out the health reports, they also edited this page to remove links to tools that provide health data from 23andMe data. So, this is interesting and useful, but not sufficient. You’ll have to look somewhere else for most tools.

23++ Chrome Extension: Get more from your data:
http://23pp.david-web.co.uk/getting-more-from-your-data/

Confessions of a Cryokid: Top 10 things to do with your FTDNA raw data (2011) http://cryokidconfessions.blogspot.com/2011/06/top-10-things-to-do-with-your-ftdna-raw.html

Genetic Genealogist: What Else Can I Do With My DNA Results: http://www.thegeneticgenealogist.com/2013/09/22/what-else-can-i-do-with-my-dna-test-results/

International Society of Genetic Genealogy: Autosomal DNA Tools: http://www.isogg.org/wiki/Autosomal_DNA_tools

Resqua: Q: What should I do after generating my Gene variance report? http://resqua.com/100005927200207/what-should-i-do-after-generating-my-gene-variance-report

Think Exponential: Get SNPd! http://thinkexponential.com/2013/01/10/why-you-should-get-snped/

PART TWO (B): Less Easy Way

Linking Disease Associations with Regulatory Information in the Human Genome

Actually, there are a LOT of different “less easy ways.” You can open the raw data file in a text editor and search manually for specific pieces of information. Or, if you code, you can write a little program to do some of the hard work for you.

Basically, it comes down to doing a lot of research, the hard way, by hand. But, believe it or not, I am doing it. I’ve had a lot of help from people who offered tips or comments in the 23andMe or MTHFR.net forums, on Facebook, on Twitter, and comments on these blogs. I am NOT an expert, but like most readers of this blog, just someone who wants or needs to know more. This is what I’ve learned and figured out on my own, offered as an example, nothing more.

Critical Background

23andMe gives SNP-based data. SNP stands for single nucleotide polymorphism. Polymorphism means something that can be itself but in different ways, our eyes are eyes whether they are blue or brown or hazel or violet or any other natural eye color. I won’t give an introduction to genetics here, but there are several online resources that explain these ideas, with one of the best resources being Genetic Home Reference from the US government. Depending on how much you want to know, you may wish to take the Coursera courses Introduction to Genetics and Evolution (Duke U) or Experimental Genome Science (U Penn).

1. What SNPs do you want to know about? Check here:

RegulomeDB (Stanford): Linking Disease Associations with Regulatory Information in the Human Genome: http://regulomedb.org/GWAS/

I have also found SNPs of interest in research articles, PUBMED, and other places, but this is a good start. The SNP identifier (what you need) will look something like this:

rs2187668

2. Find out which polymorphism is the one considered “healthy” or “normal”, and which one is the one associated with risk of disease? These maybe called “risk alleles” or
simply polymorphisms.

For example, for SNP “rs2187668″ (one of the celiac risk SNPs) the risk indicator is (T), while the normal is (C).

3. Open your 23andMe raw data file in a text editor, like WordPad (Windows) or TextEdit or TextWrangler (Macintosh).

4. Search for the SNP you want to know about. The data will be in four columns:
– RSID
– Chromosome
– Position
– Genotype
You need to know about the first and last columns, RSID and Genotype. It will look a little like this.

rsid…..chromosome…..position…..genotype
… [many other rows of data] …
rs2187668…..6………32605884…..CT

So, this person (me) has for that SNP one risk allele “T,” (which I happen to know is from my dad, by comparing it to his scan) and one normal allele “C,” (which must, by default, be from my mom, since for every gene pair we have gotten one from each parent).

5. Repeat for all the other SNPs associated with the condition you are researching.

6. Search for more information and articles about those SNPs, the condition, and more. You can’t make sense of this without more information. And ask lots of questions.

More Tools

ENCODE:
About: http://www.genome.gov/encode/
Data: http://genome.ucsc.edu/encode/

ENSEMBL Genome Browser: http://useast.ensembl.org/

OpenSNP: https://opensnp.org/ OR https://opensnp.org/snps/

SNPedia: http://www.snpedia.com/

UCSC Genome Browser: http://genome.ucsc.edu/